In the first episode of the CAP-IT Podcast, Dr. Margie Clapper, a cancer prevention researcher at Fox Chase Cancer Center, sits down with patient advocate Erica Kirschner of the Li-Fraumeni Syndrome Association for a candid conversation about living with hereditary cancer risk and the promise of cancer prevention and interception. Together, they explore the challenges faced by high-risk individuals, the importance of genetic testing and patient–scientist collaboration, and how CAP-IT research aims to intervene at the earliest stages of cancer development before a tumor can even be detected.